High-pressure high-temperature phase diagram of organic crystal paracetamol
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2016-01-06 |
| Journal | Journal of Physics Condensed Matter |
| Authors | Spencer J. Smith, Jeffrey Montgomery, Yogesh K. Vohra |
| Institutions | University of Alabama at Birmingham |
| Citations | 9 |
Abstract
Section titled āAbstractāHigh-pressure high-temperature (HPHT) Raman spectroscopy studies have been performed on the organic crystal paracetamol in a diamond anvil cell utilizing boron-doped heating diamond anvil. Isobaric measurements were conducted at pressures up to 8.5 GPa and temperature up to 520 K in five different experiments. Solid state phase transitions from monoclinic Form I ā orthorhombic Form II were observed at various pressures and temperatures as well as transitions from Form II ā unknown Form IV. The melting temperature for paracetamol was observed to increase with increasing pressures to 8.5 GPa. This new data is combined with previous ambient temperature high-pressure Raman and x-ray diffraction data to create the first HPHT phase diagram of paracetamol.