Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2016-07-25 |
| Journal | Proceedings of the National Academy of Sciences |
| Authors | Teruhiko Matsubara, Michiko Ujie, Takashi Yamamoto, Miku Akahori, Yasuaki Einaga |
| Institutions | Keio University |
| Citations | 61 |
Abstract
Section titled āAbstractāSignificance A large number of people suffer from influenza every year. Early detection is critical for preventing severe influenza in high-risk groups. There is usually not enough time to produce vaccines against pandemic viruses before they spread to other countries. Anti-influenza therapy using neuraminidase inhibitors is effective within 30 h of the onset of symptoms. Here we show that several dozen plaque-forming units of influenza virus (IFV) are detectable by a boron-doped diamond electrode terminated with a sialic acid-mimic peptide with the ability to capture IFV. The electrode was sufficiently sensitive to detect IFV in specimens obtained in the early phase of infection. The device developed in the present work has potential applications in the highly sensitive detection of IFV to fight against influenza.