All-diamond functional surface micro-electrode arrays for brain-slice neural analysis

At a Glance

Metadata	Details
Publication Date	2016-11-15
Journal	physica status solidi (a)
Authors	Farnoosh Vahidpour, Lowry Curley, István Bíró, Matthew G. McDonald, Dieter Croux
Institutions	University of Sheffield, École Polytechnique Fédérale de Lausanne
Citations	16

Abstract

Diamond-based microelectrode arrays were fabricated by using nanocrystalline diamond as an insulating layer and conductive boron-doped in order to used them for analysis of brain cortical slices. MEA surface is solely composed of diamond, exposed to the cells. The impedance measurements showed negligible cross-talk between neighbouring diamond microelectrodes. Local field potentials related to neural signals were then successfully recorded from pharmacologically disinhibited rat cortical tissue slices, mechanically coupled on the surface of the MEA. The background signal level of the diamond MEAs was found to be lower than commercial Pt-based MEAs, under identical measurement conditions.

Tech Support

Original Source

DOI: https://doi.org/10.1002/pssa.201532347

References

2010 - In-cell recordings by extracellular microelectrodes [Crossref]
2006 - Three levels of neuroelectronic interfacing: Silicon chips with ion channels, nerve cells, and brain tissue [Crossref]
1970 - An integrated-circuit approach to extracellular microelectrodes
2002 - Selective electrical interfaces with the nervous system [Crossref]
2003 - Methods and perceptual thresholds for short-term electrical stimulation of human retina with microelectrode arrays [Crossref]
2002 - In vitro electrical properties for iridium oxide versus titanium nitride stimulating electrodes [Crossref]
2013 - Multi-electrode array technologies for neuroscience and cardiology [Crossref]
2003 - Diamond-like carbon coatings as biocompatible materials − An overview [Crossref]