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6CCVD Research

Highly Sensitive Electrochemical Bioanalysis of Unicellular Samples based on Au@Pt Nanaostructures Modified Diamond Microelectrode Arrays

At a Glance

Section titled ā€œAt a Glanceā€
MetadataDetails
Publication Date2018-04-28
Journal2018-Sustainable Industrial Processing Summit
AuthorsXuemei Wang, Hui Jiang, A. Pasquarelli, Chunmei Li, Hang Zhang

Abstract

Section titled ā€œAbstractā€

In this work, aiming at the construction of a sensitive, disposable system for the bioanalysis of unicellular samples, we report a single cell detection electrochemical (SCDE) platform based on Au@Pt nanostructures modified boron-doped nanocrystalline diamond microelectrode arrays (BNCD-MEAs) with 16 channels. The SCDE platform could be readily adapted for a highly sensitive detection of H2O2 released from stimulated single cell by ascorbic acid (AA), which could be utilized to distinguish cancer unicellular and normal unicellular ones. The Au@Pt nanostructures have good electrocatalytic activity for the H2O2 detection and were modified in the BNCD-MEAs by Pt NPs which were electrodeposited onto the BNCD-MEAs through an electrodeposition approach. As a result, this SCDE platform exhibited a wide linear range with a low detection for H2O2 determination. Furthermore, it also displayed satisfactory selectivity, excellent stability, and good reproducibility. The developed method opens a new pathway to clinical bioassay.

Tech Support

Section titled ā€œTech Supportā€

Original Source

Section titled ā€œOriginal Sourceā€

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