Boron-doped Diamond Film Electrode as Voltammetric Sensor for Cetirizine
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2018-06-10 |
| Journal | International Journal of Electrochemical Science |
| Authors | Eva CulkovĆ”, Zuzana LukĆ”ÄovĆ”-ChomistekovĆ”, Renata BellovĆ”, Danica MelicherÄĆkovĆ”, Jaroslav Durdiak |
| Institutions | Catholic University in Ruzomberok |
| Citations | 20 |
Abstract
Section titled āAbstractāElectrochemical behaviour of cetirizine on bare boron-doped diamond electrode was investigated by cyclic voltammetry in supporting electrolytes with various values of pH.Signal of cetirizine is strongly affected by pH value of media.It was found that cetirizine provides one well developed irreversible oxidation peak at the potential of 1 V vs. Ag/AgCl in phosphate buffer solution (pH = 8) and no reduction peak.Oxidation process of cetirizine is limited by diffusion and involves equal number of electrons and protons.Kinetics of charge transfer was characterized by estimation of basic kinetic parameters as formal potentials (1.310 -0.821 V), charge transfer coefficients (0.18 -0.30) and standard heterogeneous rate constants (2.3 -1.4 Ć 10 -4 cm s -1 ).Analytical performance of this reaction was examined by optimized differential pulse voltammetry.Rather low detection limit of 1.6 ļ“ 10 -8 M was achieved.This value is significantly lower than on glassy carbon electrode.The practical applicability of proposed sensing platform was confirmed by analysis of pharmaceutical preparates and human urine as typical real samples.