A microsensing system using needle-type of boron-doped diamond microsensor for the <i>in vivo</i> real-time drug monitoring.
At a Glance
Section titled âAt a Glanceâ| Metadata | Details |
|---|---|
| Publication Date | 2020-01-01 |
| Journal | Proceedings for Annual Meeting of The Japanese Pharmacological Society |
| Authors | Genki Ogata, Yasuaki Einaga, Hiroshi Hibino |
| Institutions | Keio University, Niigata University |
Abstract
Section titled âAbstractâTo understand the action and efficacy of a drug in vivo, monitoring the concentration of the compound in the target cell group and its functional response is necessary. However, in such a local region, conventional methods never allow us to measure both the pharmacokinetics and pharmacodynamics over time with high spatio-temporal resolution. We developed a microsensing system using a conductive diamond, a state-of-the-art material. This system is composed of a âneedle-type diamond microsensorâ for tracking drug concentration and a glass microelectrode for detecting cellular electrical activity. We tested bumetanide, an inhibitor for Na+,K+,2Clâcotransporter, and lamotrigine, a blocker for Na+ channel in the local space of the cochlea and brain, respectively. This technique may be applicable to a variety of drugs in vivo and contribute to promoting pharmacological researches. In this session, we will show experimental results, set-up, and procedures. We will also talk about the recent technical improvement of the system.