The “Green” Electrochemical Synthesis of Periodate
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2020-03-17 |
| Journal | Angewandte Chemie International Edition |
| Authors | Sebastian Arndt, Dominik Weis, Kai Donsbach, Siegfried R. Waldvogel |
| Institutions | PharmaZell (Germany), Johannes Gutenberg University Mainz |
| Citations | 78 |
Abstract
Section titled “Abstract”Abstract High‐grade periodate is relatively expensive, but is required for many sensitive applications such as the synthesis of active pharmaceutical ingredients. These high costs originate from using lead dioxide anodes in contemporary electrochemical methods and from expensive starting materials. A direct and cost‐efficient electrochemical synthesis of periodate from iodide, which is less costly and relies on a readily available starting material, is reported. The oxidation is conducted at boron‐doped diamond anodes, which are durable, metal‐free, and nontoxic. The avoidance of lead dioxide ultimately lowers the cost of purification and quality assurance. The electrolytic process was optimized by statistical methods and was scaled up in an electrolysis flow cell that enhanced the space-time yields by a cyclization protocol. An LC‐PDA analytical protocol was established enabling simple quantification of iodide, iodate, and periodate simultaneously with remarkable precision.
Tech Support
Section titled “Tech Support”Original Source
Section titled “Original Source”References
Section titled “References”- 2016 - Essential Reagents for Organic Synthesis