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6CCVD Research

A Fouling-Resistant Voltammetric Sensing System for Wearable Electroactive Biomarker Monitoring

At a Glance

Section titled ā€œAt a Glanceā€
MetadataDetails
Publication Date2020-07-17
JournalJournal of Microelectromechanical Systems
AuthorsShuyu Lin, Xuanbing Cheng, Bo Wang, Wenzhuo Yu, Diana Ly
InstitutionsUniversity of California, Los Angeles, BioElectronics (United States)
Citations7

Abstract

Section titled ā€œAbstractā€

Voltammetry-based sensing systems are suitable for wearable monitoring of electroactive biomarkers in epidermally-retrievable biofluids (e.g., sweat), as they can directly transduce the redox features of the targets into electrical signals, delivering a sample-to-answer solution. To render reliable voltammetric readouts, the fundamental challenge of biofluid-induced fouling (causing rapid and irreversible signal degradation) must be addressed-an issue which has been overlooked in the previously reported wearable sensor development methods, but widely reported in conventional voltammetric platforms. To this end, here, we devise a fouling-resistant voltammetric sensing interface that exploits an inert electrode surface (specifically, boron-doped diamond, facilitating weak adsorption of polar molecules) as well as a hydrophilic membrane coating (chitosan) to mitigate the interaction of fouling agents with the surface. Utilizing this engineered sensing interface, sub-micromolar level quantification of uric acid was demonstrated, where the sensor presented minimal interference from non-target electroactive species (within their physiologically relevant concentration range). By interfacing the developed sensor with a wireless circuit board-augmented with a dedicated analytical framework-seamless uric acid readout acquisition in sweat was achieved. The presented biofouling characterization/mitigation methodology provides a basis for wearable electroactive sensing system development.

Tech Support

Section titled ā€œTech Supportā€

Original Source

Section titled ā€œOriginal Sourceā€

References

Section titled ā€œReferencesā€
  1. 1980 - Pulse voltammetry

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