Rapid Determination of 5-Nitrofuran Ring Antibiotics in Complex Samples Using a Boron-Doped Diamond Electrode and Differential Pulse Voltammetry
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2020-12-21 |
| Journal | Analytical Letters |
| Authors | Maria-Cristina Radulescu, Madalina-Petruta Bucur, Bogdan Bucur, Gabriel Lucian Radu |
| Institutions | National Institute of Research and Development for Biological Sciences |
| Citations | 9 |
Abstract
Section titled āAbstractāA rapid, simple, and precise electrochemical method was developed for the determination of the total content of antibiotics containing a 5-nitrofuran ring with antibacterial activity including furazolidone, nitrofurazone, nitrofurantoin, and furaltadone in several samples. Boron-doped diamond electrode was used as the working electrode. The electrochemical properties of these compounds were evaluated by cyclic voltammetry. A differential pulse voltammetric method based on the cathodic reduction at high potentials was used for the determination of the total nitrofuran content in a mixture at pH 6.47. The voltammetric measurements showed that the proposed electrochemical method was able to identify the nitrofurazone from a mixture of antibiotics based on its anodic oxidation in alkaline medium (pH 10.6). This method presented good accuracy (between 94.5 and 102.5%) and precision (less than 3.94%), with calibration graphs starting from 50 nmol Lā1. The method was applied with success for the determination of total content of compounds with 5-nitrofuran ring and for the selective determination of nitrofurazone in pharmaceutical tablets and food products (milk and honey) without pretreatment of the samples.
Tech Support
Section titled āTech SupportāOriginal Source
Section titled āOriginal SourceāReferences
Section titled āReferencesā- 2001 - Electrochemical methods: Fundamentals and applications.