Blood Oxygen Sensor Using a Boron-Doped Diamond Electrode
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2022-02-22 |
| Journal | Analytical Chemistry |
| Authors | Yunita Triana, Genki Ogata, Mai Tomisaki, Irkham Irkham, Yasuaki Einaga |
| Institutions | Keio University, Institut Teknologi Kalimantan |
| Citations | 9 |
Abstract
Section titled āAbstractāThe electrochemical behavior of oxygen (O<sub>2</sub>) in blood was studied using boron-doped diamond (BDD) electrodes. Cyclic voltammogram of O<sub>2</sub> in a 0.1 M phosphate buffer solution solution containing 1 Ć 10<sup>-6</sup> M of bovine hemoglobin exhibits a reduction peak at -1.4 V (vs Ag/AgCl). Moreover, the scan rate dependence was investigated to study the reduction reaction mechanism, which was attributable to the reduction of O<sub>2</sub> to H<sub>2</sub>O<sub>2</sub> via two electrons. A linear calibration curve was observed in the concentration range of 86.88-314.63 mg L<sup>-1</sup> (<i>R</i><sup>2</sup> = 0.99) with a detection limit of 1.0 mg L<sup>-1</sup> (S/B = 3). The analytical performance was better than those with glassy carbon or platinum electrodes as the working electrode. In addition, an application to bovine blood was performed. The O<sub>2</sub> concentration in the blood measured on the BDD electrodes was compared to that measured using an OxyLite Pro fiber-optic oxygen sensor device. Both methods gave similar values of the O<sub>2</sub> concentration in the range of ā¼40 to 150 mmHg. This result confirms that BDD electrodes could potentially be used to detect the O<sub>2</sub> concentration in blood.