Sensitive and selective voltammetric method for determination of quinoline alkaloid, quinine in soft drinks and urine by applying a boron-doped diamond electrode
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2023-05-06 |
| Journal | Microchemical Journal |
| Authors | Olha Dushna, Liliya Dubenska, MariƔn Marton, Michal Hatala, MariƔn Vojs |
| Institutions | Slovak University of Technology in Bratislava, Lviv University |
| Citations | 20 |
Abstract
Section titled āAbstractāIn this paper, for the first time, the method of determination of the alkaloid of quinoline derivation, quinine (QN), was developed. A miniatured planar electrochemical cell with a working electrode, a boron-doped diamond electrode (BDDE), was used. QN is easily oxidized in a strongly acidic environment - 2 M HClO4 at a potential of Epa = +1.42 V, and in an alkaline environment. Epa = +0.94 - +1.18 V, depending on the pH of the medium at the surface of BDDE. Also, QN is reduced within wide pH ranges at the background of the Britton-Robinson buffer (Epc = ā1.11 - ā1.51 V). This enables the simultaneous determination of QN by anodic and cathodic currents. The conditions for the determination of QN were optimized. Calibration curves under optimal conditions were obtained using differential pulse voltammetry (DPV) and square-wave voltammetry (SWV). The limit of detection of QN according to the cathodic peak is at the level of 10ā7 M. According to the peak of QN oxidation, the sensitivity is worse, and the limit of detection of QN is at the level of 10ā6 M. The developed method was tested in the analysis of soft drinks. The results were compared with those of high performance liquid chromatography. The obtained results were statistically processed using the relative errors and Student t-test. Uric acid, nicotine, and caffeine, which can often be present in biological fluids, do not affect the oxidation and reduction of QN on BDDE. Various methods of urine sample preparation for voltammetric analysis were investigated. The proposed method can determine QN in urine at the level of 1.0 Ī¼g/ml of urine.
Tech Support
Section titled āTech SupportāOriginal Source
Section titled āOriginal SourceāReferences
Section titled āReferencesā- 2017 - Voltammetric methods for the determination of pharmaceuticals [Crossref]
- 2021 - Voltammetry of local anesthetics: theoretical and practical aspects [Crossref]
- 2019 - New trends in electrode systems for sensitive drug and biomolecule analysis [Crossref]
- 2019 - Electroanalysis of pharmaceuticals on boron-doped diamond electrodes: A review
- 2020 - Electroanalysis from the past to the twenty-first century: challenges and perspectives [Crossref]
- 2022 - Recent electroanalytical applications of boron-doped diamond electrodes
- 2020 - A review on recent advances in the applications of boron-doped diamond electrochemical sensors in food analysis
- 2022 - Ozkan Boron-doped diamond electrodes: recent developments and advances in view of electrochemical drug sensors [Crossref]
- 2020 - Electroanalysis of gallic and ellagic acids at a boron-doped diamond electrode coupled with high-performance liquid chromatography [Crossref]