A Selective and Sensitive Electrochemical Sensor for Pyridoxine Hydrochloride (Vitamin B6) in Pharmaceutic Tablet
At a Glance
Section titled âAt a Glanceâ| Metadata | Details |
|---|---|
| Publication Date | 2023-10-16 |
| Journal | ChemistrySelect |
| Authors | Berna Koçak |
| Institutions | Munzur University |
| Citations | 3 |
Abstract
Section titled âAbstractâAbstract In this study, a copper (II) oxideâglutardialdehyde modified boron doped diamond electrode was used as a sensor for the electroanalysis of pyridoxine hydrochloride (vitamin B6) for the first time. A copper oxideâglutardialdehyde modified boron doped diamond electrode (CuOâGA 2 /BDDE) was prepared by a simple drop casting method on boron diamond electrode (BDDE) by suspending CuO with glutardialdehyde (CuOâGA 2 ). The electrochemical behavior of vitamin B6 was examined using cyclic voltammetry (CV) and its electrochemical determination was found by differential pulse voltammetry (DPV). Under optimum experimental conditions, the linear working range of vitamin B6 on CuOâGA 2 /BDDE via the DPV method was calculated as 5.96Ă10 â6 -3.75Ă10 â4 mol.L â1 . The limit of detection (LOD) was calculated as 1.99Ă10 â7 mol.L â1 . In order to demonstrate the selectivity of the method improved for the quantitative determination of vitamin B6 on the CuOâGA 2 /BDDE, the interference effect of some cations (Zn 2+ , Cu 2+ , Pb 2+ ) and anions (NO 3 â , Cl â ) was investigated via the DPV method. The improved electrode was successfully used for the electroanalysis of vitamin B6 in a tablet sample of the commercial TribeksolÂŽ (deva) (250/250/1 mg B 1 +B 6 +B 12 ).