An affordable and green voltammetric approach for the determination of sotalol in biological, environmental, and pharmaceutical samples
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2024-03-10 |
| Journal | Electroanalysis |
| Authors | Gustavo Fix, Bruna Coldibeli, Elen RomĆ£o Sartori |
| Institutions | Universidade Estadual de Londrina |
| Citations | 2 |
Abstract
Section titled āAbstractāAbstract This work outlines the development of a voltammetric method for a sensitive, rapid, and environmentally friendly determination of the antihypertensive sotalol (SOT) in several sample types employing the anodically pretreated boronādoped diamond electrode. Cyclic voltammograms of SOT presented a wellādefined irreversible oxidation peak at 1.21 V (Ag/AgCl (3.0 mol L ā1 KCl)) in Britton-Robinson buffer solution (pH 3.0). Figures of merits recommended by the validation guidelines were evaluated for the validation of the present method. Employing differential pulse voltammetry linearity of SOT was obtained in the concentration range of 0.39-4.22 Ī¼mol L ā1 in 0.1 mol L ā1 H 2 SO 4 solution, with a limit of detection of 0.031 Ī¼mol L ā1 . The selectivity of the method was assessed against interferers and show relative standard deviation (RSD) values lower than 6 %. Recovery tests yielded percentages ranging from 93 % to 96 % in urine sample and from 100 % to 107 % in tap water sample. The proposed method was successfully applied in pharmaceutical, environmental, and biological samples offering a suitable green analytical chemistry profile.
Tech Support
Section titled āTech SupportāOriginal Source
Section titled āOriginal SourceāReferences
Section titled āReferencesā- 1980 - Pharmacology of Antihypertensive Drugs