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6CCVD Research

Mechanistic study of the electrochemical oxidation of fluoroquinolones - Ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin

At a Glance

Section titled “At a Glance”
MetadataDetails
Publication Date2024-03-22
JournalChemosphere
AuthorsMelanie Voigt, Jean-Michel Dluziak, Nils Wellen, Martin Jaeger
InstitutionsHochschule Niederrhein
Citations13

Abstract

Section titled “Abstract”

The fluoroquinolones ciprofloxacin, danofloxacin, enoxacin, levofloxacin and lomefloxacin, occur in water bodies worldwide and therefore pose a threat to the aquatic environment. Advanced purification procedures, such as electrochemical oxidation, may act as a remedy since they contribute to eliminating contaminants and prevent micropollutants from entering open water bodies. By electrochemical treatment in a micro-flow reactor equipped with a boron-doped diamond (BDD) electrode, the fluoroquinolones were efficiently degraded. A total of 15 new products were identified using high-performance high-resolution chromatography coupled with high-resolution multifragmentation mass spectrometry. The ecotoxicity of the emerging transformation products was estimated through in silico quantitative structure activity relationship analysis. Almost all transformation products were predicted less ecotoxic than the initial compounds. The fluoroquinolone degradation followed three major mechanisms depending on the voltage during the electrochemical oxidation. At approximately 1 V, the reactions started with the elimination of molecular hydrogen from the piperazine moiety. At approx. 1.25 V, methyl and methylene groups were eliminated. At 1.5 V, hydroxyl radicals, generated at the BDD electrode, led to substitution at the piperazine ring. This novel finding of the three reactions depending on voltage contributes to the mechanistic understanding of electrochemical oxidation as potential remedy against fluoroquinolones in the aquatic environment.

Tech Support

Section titled “Tech Support”

Original Source

Section titled “Original Source”

References

Section titled “References”
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  4. 2020 - Understanding the electrochemical oxidation of dyes on platinum and boron-doped diamond electrode surfaces: experimental and computational study [Crossref]
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  8. 2018 - Assessment of sulfate radical-based advanced oxidation processes for water and wastewater treatment: a review [Crossref]
  9. 2019 - Recent developments and advances in boron-doped diamond electrodes for electrochemical oxidation of organic pollutants [Crossref]

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