Electrochemical Oxidation of Ranitidine using a Boron-Doped Diamond Electrode in the Presence of Anionic Surfactant - A Comprehensive Investigation
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2024-06-29 |
| Journal | Cumhuriyet Science Journal |
| Authors | Hasret Subak, Pınar Talay Pınar |
| Institutions | Van YĆ¼zĆ¼ncĆ¼ Yıl Ćniversitesi |
Abstract
Section titled āAbstractāRanitidine (RAN) is a drug from the histamine H2 receptor antagonist class and is used to prevent excessive production of stomach acid. An electrochemical investigation of the RAN in pharmaceutical preparation and spiked human urine was performed for the using a boron-doped diamond electrode (BDDE). Voltammetric measurements were performed in a pH 11 BR solution supplemented with the anionic surfactant, sodium dodecyl sulfate (SDS). In the proposed method using optimized experimental conditions, linearity was obtained for RAN in the concentration range of 0.8-50.0 Ī¼M. The LOD value obtained is 0.22 Ī¼M. Good selectivity, accuracy, precision, and acceptable repeatability were also achieved in this proposed electrochemical sensor. Finally, this electrochemical sensor was successfully used for RAN detection in pharmaceutical samples.