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6CCVD Research

Diamond-coated quartz crystal microbalance sensors - Challenges in high yield production and enhanced detection of ethanol and sars-cov-2 proteins

At a Glance

Section titled “At a Glance”
MetadataDetails
Publication Date2024-11-26
JournalMaterials & Design
AuthorsTibor Izsák, M. Varga, Michal Kočí, Ondrej Szabó, Kateřina Aubrechtová Dragounová

Abstract

Section titled “Abstract”

This study presents the technological progress in the deposition of diamond thin films on quartz crystal microbalance (QCM) sensors. The linear antenna microwave plasma chemical vapour deposition (CVD) technique effectively grows thin diamond films on QCM substrates (Dia-QCM) differently oriented on the substrate holder in the deposition chamber, resulting in single-sided and double-sided coated QCMs. Each of these coated QCMs offers a distinctive advantage for sensing applications. The double-sided coated QCM sensors exhibited the most effective performance in ethanol detection, demonstrating approx. a 3-fold and 12-fold higher response than single-sided diamond-coated and bare gold QCM sensors, respectively. Furthermore, the single-sided Dia-QCM aptasensors demonstrated superior performance compared to bare gold QCM sensors, with a 2-fold higher response and a lower detection limit for S-RBD protein (LODDia-QCM = 0.09 pg/mL vs. LODAu-QCM = 0.10 pg/mL). In experiments conducted in human plasma, the Dia-QCM aptasensor demonstrated the ability to detect S-RBD protein at concentrations as low as 50 pg/mL, with high percentage recoveries. These results highlight the potential of linear antenna microwave plasma CVD for the mass production of advanced diamond-coated QCM sensors with different diamond film morphologies (porous, micro- or nanocrystalline) for various applications.

Tech Support

Section titled “Tech Support”

Original Source

Section titled “Original Source”

References

Section titled “References”
  1. 2017 - Quartz crystal microbalance electronic interfacing systems: A review [Crossref]
  2. 2021 - Quartz Crystal Microbalance (QCM) sensing materials in biosensors development [Crossref]
  3. 2018 - Review about the development of the differential expression QCM system [Crossref]
  4. 2015 - Quartz-crystal microbalance (QCM) for public health [Crossref]
  5. 2020 - Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases [Crossref]
  6. 2023 - Real-time biosensing bacteria and virus with quartz crystal microbalance: Recent advances, opportunities, and challenges
  7. 2023 - Sensing properties of g-C3N4/Au nanocomposite for organic vapor detection [Crossref]
  8. 2023 - Goswamy, Improved room temperature ethanol vapors sensing using silver nanoparticles decorated graphitic carbon nitride (Ag-gCN) nanocomposite [Crossref]
  9. 2003 - Neuromotor effects of acute ethanol inhalation exposure in humans: A preliminary study [Crossref]
  10. 2021 - A review on environmental gas sensors: Materials and technologies

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