Voltammetric determination of lercanidipine in urine, blood plasma, and serum using hollow fiber-based liquid phase microextraction
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2025-04-05 |
| Journal | Talanta |
| Authors | Oleksandra Labzova, Vojtěch Hrdlička, Renáta Šelešovská, Tomáš Navrátil |
| Institutions | University of Pardubice, Czech Academy of Sciences, J. Heyrovský Institute of Physical Chemistry |
| Citations | 1 |
Abstract
Section titled “Abstract”This study investigates a synergistic combination of hollow fiber-based liquid phase microextraction (HF-LPME) and voltammetric analysis using screen-printed boron-doped diamond electrodes (SP-BDDE) for the determination of antihypertensive drug lercanidipine (LCN) in urine, blood plasma, and blood serum. Optimum HF-LPME conditions were: dodecane as supported liquid membrane, Britton-Robinson buffer (BRB) pH 7 as donor solution, BRB pH 3 as acceptor solution, and extraction time 30 min. Square-wave voltammetry (SWV) of 10 μL acceptor solution at SP-BDDE was utilized with amplitude 75 mV, frequency 10 Hz, and potential step 4 mV. The calibration dependence of the combined HF-LPME-SWV method was established in the range of 1-1000 nmol L<sup>-1</sup>, with limits of quantification (LOQ) and detection (LOD) of 3.3 and 1.1 nmol L<sup>-1</sup>, respectively. The applicability of the developed method was verified by analysis of human urine, blood plasma, and blood serum samples spiked with 20 and 100 nmol L<sup>-1</sup> LCN with recoveries ranging from 93.2 to 112.9 % with respective RSDs 1.72-8.5 % (n = 3).
Tech Support
Section titled “Tech Support”Original Source
Section titled “Original Source”References
Section titled “References”- 2005 - Lercanidipine in hypertension
- 2023 - New insights into the nephroprotective potential of lercanidipine [Crossref]
- 2010 - Blood pressure and metabolic effects of a combination of lercanidipine with different antihypertensive drugs in clinical practice [Crossref]
- 2005 - Quantitative determination of the calcium channel antagonists amlodipine, lercanidipine, nitrendipine, felodipine, and lacidipine in human plasma using liquid chromatography-tandem mass spectrometry [Crossref]
- 1987 - Electrochemical oxidation mechanisms of different type-1,4-dihydropyridine derivatives in acetonitrile [Crossref]
- 2019 - Electroanalytical methods for determination of calcium channel blockers [Crossref]
- 2002 - Differential pulse voltammetric assay of lercanidipine in tablets [Crossref]
- 2020 - Calcium channel blocker lercanidipine electrochemistry using a carbon black-modified glassy carbon electrode [Crossref]
- 2011 - A new voltammetric method for the determination of lercanidipine in biological samples
- 2014 - Voltammetric behavior of lercanidipine and anodic adsorptive stripping voltammetric method for assay in pharmaceutical dosage forms and biological fluids