Advanced Approach towards Electrochemical Oxidation and Determination of Aripiprazole Using Gold and Boron-Doped Diamond Electrodes
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2025-05-01 |
| Journal | Journal of The Electrochemical Society |
| Authors | Nebojša D. Nikolić, Sanja Mutić, Sanja Stevanović, Dušan Mijin, Slobodan Petrović |
Abstract
Section titled “Abstract”The antipsychotic drug aripiprazole (ARP) can be determined at the trace level in biological samples employing an easy-to-use and very sensitive electrochemical approach. The cyclic voltammetric behavior of ARP at the gold (Au) electrode and the boron-doped diamond electrode (BDDE) was investigated and suggested that the ARP oxidation process is irreversible and adsorption-controlled. The morphology of ARP on the Au electrode surface was studied using optical microscopy and atomic force microscopy techniques. The various experimental parameters of the SW-AdSV method were optimized for the quantitative determination of ARP at the anodically pretreated BDDE (+2.4 V; 60 s). Under optimized conditions (pH 3.0; accumulation potential (E acc ) of 0.5 V and accumulation time (t acc ) of 180 s), a linear concentration range was from 0.10 ng ml −1 to 16.91 ng ml −1 , while the relative standard deviation did not exceed 4.6%, and the evaluated detection limit (LOD) was 0.03 ng ml −1 . The interference study confirmed adequate selectivity of the proposed SW-AdSV method and BDDE towards ARP. During the analysis of ARP in spiked urine sample, good recovery and reproducibility were achieved, suggesting a good application capability and reliability of the developed voltammetric method for monitoring ARP in biological samples.