Engineered NanoDiamond particles for imaging neural activity
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2015-01-01 |
| Journal | Frontiers in Neuroscience |
| Authors | Antonina Monaco, Motylewski Jaroslaw, Singam Shashi Kanth Reddy, Goovaerts Etienne, MichĆØle Giugliano |
Abstract
Section titled āAbstractāEvent Abstract Back to Event Engineered NanoDiamond particles for imaging neural activity Antonina Monaco1, Jaroslaw Motylewski1, Shashi Kanth Reddy Singam2, Etienne Goovaerts2 and Michele Giugliano1, 3, 4* 1 University of Antwerp, Theoretical Neurobiology and Neuroengineering Laboratory, Dept. of Biomedical Sciences, Belgium 2 University of Antwerp, Department of Physics, Belgium 3 Brain Mind Institute, Swiss Federal Institute of Technology Lausanne, Switzerland 4 University of Sheffield, Dept. Computer Science, United Kingdom Nowadays, the gap between material sciences and biology has become more and more narrow, thus enabling substantial progress within interdisciplinary approaches. One of the most fruitful results of this new approach is the use of carbon-based nanomaterials in biological and biomedical sciences, where they found use as nanostructured substrates for cellular growth and regeneration, as labels for cellular imaging and as nanoscale electrodes (Chang et al., 2008; Cellot et al., 2009; Li et al., 2013; Monaco and Giugliano, 2014; Tang-Schomer et al., 2014). These applications, however, though improving stimulation and recording conditions in terms of a reduced Signal/Noise ratio, find limitation in their invasive character, as well as in their spatial and temporal resolution. This calls for the development of non-invasive techniques, which allow localizing brain structures on the order of micrometres and measuring neural function on a temporal scale of few milliseconds. To this purpose, we are exploring the use of Nitrogen Vacancy Nanodiamonds (NV-NDs) to image single cell and network-level activity to directly evaluate the local electromagnetic fields generated by neuronal activity by means of spin sensitive photon detection (Hall et al., 2012). These NV-NDs, in fact, are one of the most powerful sensors of magnetic field, thanks to the high sensitivity of their electron spin states to light and to magnetic field. This aspect, combined with the already proven high biocompatibility of nanodiamonds, makes NV-NDs promising candidates to be used as nanoscopic magnetic sensors of spin labels. References Cellot, G., Cilia, E., Cipollone, S., Rancic, V., Sucapane, A., Giordani, S., Gambazzi, L., Markram, H., Grandolfo, M., Scaini, D., Gelain, F., Casalis, L., Prato, M., Giugliano, M., and Ballerini, L. (2009). Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts. Nat Nanotechnol 4, 126-133. doi: 10.1038/nnano.2008.374. Chang, Y.R., Lee, H.Y., Chen, K., Chang, C.C., Tsai, D.S., Fu, C.C., Lim, T.S., Tzeng, Y.K., Fang, C.Y., Han, C.C., Chang, H.C., and Fann, W. (2008). Mass production and dynamic imaging of fluorescent nanodiamonds. Nat Nanotechnol 3, 284-288. doi: 10.1038/nnano.2008.99. Hall, L.T., Beart, G.C., Thomas, E.A., Simpson, D.A., Mcguinness, L.P., Cole, J.H., Manton, J.H., Scholten, R.E., Jelezko, F., Wrachtrup, J., Petrou, S., and Hollenberg, L.C. (2012). High spatial and temporal resolution wide-field imaging of neuron activity using quantum NV-diamond. Sci Rep 2, 401. doi: 10.1038/srep00401. Li, N., Zhang, Q., Gao, S., Song, Q., Huang, R., Wang, L., Liu, L., Dai, J., Tang, M., and Cheng, G. (2013). Three-dimensional graphene foam as a biocompatible and conductive scaffold for neural stem cells. Sci Rep 3, 1604. doi: 10.1038/srep01604. Monaco, A.M., and Giugliano, M. (2014). Carbon-based smart nanomaterials in biomedicine and neuroengineering. Beilstein Journal of Nanotechnology 5, 1849-1863. doi: 10.3762/bjnano.5.196. Tang-Schomer, M.D., White, J.D., Tien, L.W., Schmitt, L.I., Valentin, T.M., Graziano, D.J., Hopkins, A.M., Omenetto, F.G., Haydon, P.G., and Kaplan, D.L. (2014). Bioengineered functional brain-like cortical tissue. Proc Natl Acad Sci U S A 111, 13811-13816. doi: 10.1073/pnas.1324214111. Keywords: Nitrogen Vacancy Nanodiamonds, Neuronal activity, neuronal imaging, Neural electromagnetic field, primary neuronal culture Conference: 11th National Congress of the Belgian Society for Neuroscience, Mons, Belgium, 22 May - 22 May, 2015. Presentation Type: Poster presentation Topic: Neuroscience Citation: Monaco A, Motylewski J, Singam S, Goovaerts E and Giugliano M (2015). Engineered NanoDiamond particles for imaging neural activity. Front. Neurosci. Conference Abstract: 11th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2015.89.00079 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiersā terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 30 Apr 2015; Published Online: 05 May 2015. * Correspondence: Prof. Michele Giugliano, University of Antwerp, Theoretical Neurobiology and Neuroengineering Laboratory, Dept. of Biomedical Sciences, Wilrijk, Belgium, [email protected] Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Antonina Monaco Jaroslaw Motylewski Shashi Kanth Reddy Singam Etienne Goovaerts Michele Giugliano Google Antonina Monaco Jaroslaw Motylewski Shashi Kanth Reddy Singam Etienne Goovaerts Michele Giugliano Google Scholar Antonina Monaco Jaroslaw Motylewski Shashi Kanth Reddy Singam Etienne Goovaerts Michele Giugliano PubMed Antonina Monaco Jaroslaw Motylewski Shashi Kanth Reddy Singam Etienne Goovaerts Michele Giugliano Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. 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