Electrochemical Amination of Less‐Activated Alkylated Arenes Using Boron‐Doped Diamond Anodes
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2016-02-12 |
| Journal | European Journal of Organic Chemistry |
| Authors | Sebastian Herold, Sabine Möhle, Michael Zirbes, Frank Richter, Hartmut Nefzger |
| Institutions | Covestro (Germany), Johannes Gutenberg University Mainz |
| Citations | 71 |
Abstract
Section titled “Abstract”Abstract The anodic C-H amination of aromatic compounds is a powerful and versatile method for the synthesis of aniline derivatives. By using boron‐doped diamond (BDD) anodes, a method initially described by Yoshida et al. for electron‐rich arenes was expanded to less‐activated aromatic systems e.g., simple alkylated benzene derivatives. Anodes based on sp 3 carbon seem to be the key for the electrochemical amination reaction. The corresponding primary anilines are obtained in good yields. Despite the cationic intermediates of the electrolytic reaction tert ‐butyl moieties are tolerated.