Skip to content

Unsymmetrical Biaryl Compounds - Metal‐ and Reagent‐Free Electrochemical Couplings Are on the Advance

MetadataDetails
Publication Date2017-10-19
JournalAngewandte Chemie International Edition
AuthorsHans J. Schäfer
InstitutionsUniversity of Münster
Citations20

It’s electrifying! Electrochemical cross-coupling of aryl compounds provides a one-step approach to unsymmetrical biaryl compounds. A boron-doped diamond electrode is used as the anode to oxidise the phenolic hydroxy group to a phenoxy radical, with 1,1,1,3,3,3-hexafluoroisopropylalcohol (HFIP) and tetraalkylammonium methylsulfate used as the solvent and electrolyte. Since no reagents are required, no waste is formed from this source.

  1. 2016 - Organic Electrochemistry, 5th ed.