Electrochemical Behaviour of Ofloxacin in Pharmaceutical and Biological Samples Using a Boron-Doped Diamond Electrode in Using Anionic Surfactant
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2018-03-01 |
| Authors | Pınar Talay Pınar |
| Citations | 10 |
Abstract
Section titled āAbstractāThis paper examined use of a boron doped diamondelectrode (BDDE) for the electroanalysis of ofloxacin (one of the fluoroquinolone compounds) bycyclic voltammetry (CV) and square wave voltammetry (SWV) in the presence ofanionic surfactant (SDS) for the first time. The current signal due to theoxidation process was a function of the amount of ofloxacin, pH of the medium, effectof anionic surfactant (sodium dodecyl sulfate) and scan rate. Cyclic voltammetric studies indicated an irreversiblebehaviour of ofloxacin in phosphate buffer solution at pH 2.0 with well-definedoxidation peak at +1.24 V (absence SDS) and +1.21 V (presence of SDS) vs. Ag/AgCl,respectively. With optimizedexperimental parameters, the current response of ofloxacin was proportionallylinear in the concentration range from 1.0Ć10-7 to 3.5Ć10-6 M. Adetection limit of 1.76Ć10-8 Mwas observed anodically electrochemical surface pretreatments. The practical applicability of the developed methodwas demonstrated on the determination of ofloxacin in human urine andpharmaceutical samples. Inthis way, BDD electrode may represent an efficient alternative to widely usedmodified electrodes in the determination of fluoroquinolonecompounds.
Tech Support
Section titled āTech SupportāOriginal Source
Section titled āOriginal Sourceā- DOI: None