Molecular Functionalization of Planar Nanocrystalline and Porous Nanostructured Diamond to Form an Interface with Newborn and Adult Neurons
At a Glance
Section titled âAt a Glanceâ| Metadata | Details |
|---|---|
| Publication Date | 2018-12-27 |
| Journal | physica status solidi (b) |
| Authors | Jan KrĹŻĹĄek, Ivan Dittert, Tereza SmejkalovĂĄ, Miloslav KoĹÄąĚnek, KristĂ˝na GottfriedovĂĄ |
| Institutions | Czech Academy of Sciences, Institute of Physics, Czech Academy of Sciences, Institute of Physiology |
| Citations | 11 |
Abstract
Section titled âAbstractâThis article examines the ability of newly developed nanostructured porous boronâdoped diamond (BDD) to form an interface with neural cells and the role of molecular functionalization by a polymer on this interface. Due to its high stability, biocompatibility, and electrical properties, BDD is a promising material for construction of neuroelectrodes. Nanostructuring and an increase in the surface specific area can further improve the sensitivity and performance of such electrodes. Here, porous BDD prepared in a multistep diamond deposition on a porous template consisting of a polymer and electrospun SiO 2 fibers is examined. This work shows that this new material is biocompatible and does not exhibit any cytotoxicity on fibroblast cell lines. Further, this work shows that porous BDD supports regeneration of newborn and adult neurons when functionalized with polyâLâlysine.