Voltammetry as the First Method for Direct Determination of a Novel Antagonist of A2A Adenosine Receptors
At a Glance
Section titled âAt a Glanceâ| Metadata | Details |
|---|---|
| Publication Date | 2019-08-07 |
| Journal | Electroanalysis |
| Authors | Katarzyna TyszczukâRotko, MaĆgorzata Sztanke, Agnieszka Sasal, Krzysztof Sztanke |
| Institutions | Medical University of Lublin, Maria Curie-SkĆodowska University |
| Citations | 2 |
Abstract
Section titled âAbstractâAbstract In this article, for the first time, the analytical method for determination of a novel antagonist of A 2A adenosine receptors (8â(4âmethoxyphenyl)â4âoxoâ4,6,7,8âtetrahydroimidazo[2,1â c ][1,2,4]triazineâ3âcarbohydrazide, namely IMT), which can be used as a drug for liver diseases, was presented. For this purpose a commercially available boronâdoped diamond electrode (BDDE) in combination with differential pulse voltammetry (DPV) was applied. It was found by cyclic voltammetry (CV) that IMT displays at BDDE, as a sensor, two wellâdefined oxidation peaks at potentials of 0.81 and 1.18 V and one reduction peak at 1.1 V vs. Ag/AgCl in 0.1 mol L â1 acetate buffer (pH 4.5±0.1). The oxidation and reduction mechanism of IMT was proposed. The developed DPV method allowed the successful determination of IMT in the range of 0.05-50 ÎŒmol L â1 with detection limit equal to 0.0094 ÎŒmol L â1 and without any chemical modifications and electrochemical pretreatment of the electrode surface. The proposed procedure allows the determination of IMT in vitro directly from urine samples.