Nanoscale Dynamic Readout of a Chemical Redox Process Using Radicals Coupled with Nitrogen-Vacancy Centers in Nanodiamonds
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2020-08-06 |
| Journal | ACS Nano |
| Authors | Jan BartoÅ, Michal Gulka, JĆ”n TarĆ”bek, Yuliya Mindarava, Zhenyu Wang |
| Institutions | UniversitƤt Ulm, Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry |
| Citations | 108 |
Abstract
Section titled āAbstractāBiocompatible nanoscale probes for sensitive detection of paramagnetic species and molecules associated with their (bio)chemical transformations would provide a desirable tool for a better understanding of cellular redox processes. Here, we describe an analytical tool based on quantum sensing techniques. We magnetically coupled negatively charged nitrogen-vacancy (NV) centers in nanodiamonds (NDs) with nitroxide radicals present in a bioinert polymer coating of the NDs. We demonstrated that the T1 spin relaxation time of NV centers is very sensitive to the number of nitroxide radicals, with a resolution down to ~10 spins per ND (detection of approximately 10-23 mol in a localized volume). The detection is based on T1 shortening upon the radical attachment and we propose a theoretical model describing this phenomenon. We further show this colloidally stable, water-soluble system can be used dynamically for spatiotemporal readout of a redox chemical process (oxidation of ascorbic acid) occurring near the ND surface in an aqueous environment under ambient conditions.