New Voltammetric Strategy for Determination and Electrochemical Behaviors of Oxaliplatin by CPT-BDD Electrode
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2020-10-01 |
| Journal | Zenodo (CERN European Organization for Nuclear Research) |
| Authors | Mehmet Aslan, Abdulkadır Levent |
| Citations | 2 |
Abstract
Section titled āAbstractā<p>Department of Chemistry, Science Institute, Dicle University, 21280 Diyarbakir, Turkey"a"</p> <p>Batman University, Faculty of Sciences and Arts, Department of Chemistry,72100, Batman, Turkey"b"</p> <p>E-mail: [[email protected]]</p> <p>Manuscript Received online 10/20/2020, Accepted 11/1/2020</p> <p>In this study, a simple, fast and sensitive voltammetric method was developed for oxaliplatin (OxPt), which shows anticancer effects with cytotoxic properties. The boron-doped diamond (BDD) electrode was activated electrochemically in cathodic direction in 0.5 M H<sub>2</sub>SO<sub>4</sub> medium. Electrochemical properties of OxPt were investigated on BDD electrode surface using square-wave (SW) and cyclic voltammetry techniques. OxPt in Britton-Robinson (BR) buffer (pH 5.0) gave a well-determined voltammetric response at +1.01 V (vs. Ag/AgCl) using the SW voltammetry technique. The developed voltammetric technique was found to be linear with the concentration range of 1.0-3.5 μM in the BR (pH 5.0) medium and the limit of detection was 0.276 μM (0.109 μgmL<sup>-1</sup> ). Recommended method was successfully applied to drug forms of OxPt.</p>