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Development of a novel Voltammetric method for the Loperamide determination in Environmental and biological samples - In-house validation and greenness

At a Glance

Section titled ā€œAt a Glanceā€
MetadataDetails
Publication Date2024-03-30
JournalGreen Analytical Chemistry
AuthorsBruna Coldibeli, Gustavo Fix, Elen RomĆ£o Sartori
InstitutionsUniversidade Estadual de Londrina
Citations4

Abstract

Section titled ā€œAbstractā€

Loperamide hydrochloride is a pharmacological agent widely consumed by humans in the treatment of diarrhea. Therefore the development and validation of green and reliable analytical methods for its determination in different samples is of great importance. So, we describe here the use of a boron-doped diamond electrode in combination with differential pulse voltammetry to develop and in-house validate an analytical method for the determination of loperamide. The electrochemical characterization showed a diffusion-controlled mass transfer upon the electrode surface. The method was validated according to the recommendations of validation guidelines. Linearity was obtained in the loperamide concentration range of 1.50 - 21.05 Āµmol Lāˆ’1 in Britton Robinson buffer solution (pH 9.0). The limit of detection and limit of quantitation were calculated as 0.41 Āµmol Lāˆ’1 and 1.24 Āµmol Lāˆ’1, respectively. The developed method presented adequate selectivity, precision, and accuracy for the quantitative measurement of loperamide in environmental and biological samples. In addition, the described voltammetric method offered a suitable green analytical chemistry profile.

Tech Support

Section titled ā€œTech Supportā€

Original Source

Section titled ā€œOriginal Sourceā€

References

Section titled ā€œReferencesā€
  1. 1999 - Green chemistry and the role of analytical methodology development [Crossref]
  2. 2013 - The 12 principles of green analytical chemistry and the SIGNIFICANCE mnemonic of green analytical practices [Crossref]
  3. 2018 - A review of the identification and detection of heavy metal ions in the environment by voltammetry [Crossref]
  4. 2018 - Sensors for voltammetric determination of food azo dyes - A critical review [Crossref]
  5. 2022 - Assessing the food quality using carbon nanomaterial based electrodes by Voltammetric techniques [Crossref]
  6. 2022 - Reviewā€”Recent advances of electrochemical techniques in food, energy, environment, and forensic applications
  7. 2021 - Contemporary voltammetric techniques and its application to pesticide analysis: a review [Crossref]
  8. 2022 - Advanced sensor materials for the simultaneous Voltammetric determination of antihypertensive drugs: an overview [Crossref]
  9. 2023 - A green Voltammetric determination of Molnupiravir using a disposable screen-printed reduced graphene oxide electrode: application for pharmaceutical dosage and biological fluid forms [Crossref]
  10. 2024 - Nanostructured materials-based electrochemical biosensor devices for quantification of antioxidants

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