Electroanalytical Determination of Trimetazidine in Pharmaceuticals and Synthetic Urine Using an Anodically Treated Boron-Doped Diamond (BDD) Electrode and Square Wave Voltammetry (SWV)
At a Glance
Section titled âAt a Glanceâ| Metadata | Details |
|---|---|
| Publication Date | 2024-03-01 |
| Journal | Analytical Letters |
| Authors | C. L. L. G. de Oliveira, Mauro C. Santos, OdonıÌrio AbrahĂŁo, Renata Pereira Alves, Ricardo JosĂ© de Mendonça |
| Institutions | Universidade Federal do TriĂąngulo Mineiro, Universidade Federal do ABC |
Abstract
Section titled âAbstractâTrimetazidine dihydrochloride is an anti-ischemic agent widely used in the treatment of coronary artery disease, more specifically in the treatment of angina. Here is reported a simple and sensitive electroanalytical methodology for quantifying trimetazidine in pharmaceutical and synthetic urine samples using square-wave voltammetry. The influence of anodic and cathodic treatments on boron-doped diamond (BDD) was evaluated. The best results for trimetazidine were obtained using a BDD treated anodically at +3.0 V versus Ag(s)/AgCl(s)/Cl-(aq., saturated KCl) for 300 s in 0.1 mol Lâ1 H2SO4. The determination of trimetazidine was carried out in Britton-Robinson buffer at pH 3. Trimetazidine oxidation reveals two well-defined irreversible oxidation peaks. A calibration relationship was obtained from 0.35 mg L-1 to 2.6 mg Lâ1 (R2 = 0.997). Limits of detection and quantification for trimetazidine were 5.63 x 10â9 and 1.88 x 10â8 mol Lâ1, respectively. Recovery values were between 97 and 101 % and 96.8 and 99.8 % in pharmaceutical and synthetic urine.
Tech Support
Section titled âTech SupportâOriginal Source
Section titled âOriginal SourceâReferences
Section titled âReferencesâ- 2011 - Spectrophotometric method for determination of trimetazidine in formulation using chloranil as chromogenic agent