Skip to content

Development of a compact and portable diamond-based detection system for dosimetry and microdosimetry in ion beam therapy

MetadataDetails
Publication Date2024-11-01
JournalReview of Scientific Instruments
AuthorsC. Verona, Andrea Fabbri, A. Fazzi, Lucrezia Bianchi, V. Conte
InstitutionsRoma Tre University, Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali del Sud
Citations2

Ion beam therapy techniques have advanced significantly in the past two decades. However, the development of dosimetric verification methods has lagged. Traditional dosimetry, which offers a macroscopic view of the absorbed dose, fails to address the micrometric-scale stochastic effects crucial for understanding biological responses. To bridge this gap, microdosimeters are used to assess physical quantities correlated with radiation effects. This work reports on the design and testing of a novel detection system based on synthetic single crystal diamond. The system is capable of simultaneously performing dosimetric and microdosimetric characterizations of clinical ion beams. The detector incorporates two active components configured as diamond Schottky diodes, both integrated on a single crystal diamond substrate. In particular, one very small element (sensitive area 0.0078 mm2) was designed to evaluate microdosimetric metrics, while the other large one (sensitive area 4.2 mm2) was designed to measure the absorbed dose to water. Diamond detectors were characterized using the ion beam induced charge (IBIC) technique, employing a 1 MeV protons microbeam. The IBIC map of the diamond detector shows two distinct sensitive areas with quite uniform sensitivity, well contained within the metallic contact regions. Dedicated front-end electronic circuits were designed and implemented for both the dosimetric and microdosimetric signals. These circuits, along with the integrated diamond detector, were embedded in an aluminum waterproof housing to minimize electronic interference. This configuration enables a compact, portable setup compatible with water phantoms. Laboratory tests with alpha particles yielded promising results, demonstrating stable and reproducible responses with a good signal-to-noise ratio.

  1. 2010 - Charged particles in radiation oncology [Crossref]
  2. 2010 - Heavy-ion tumor therapy: Physical and radiobiological benefits [Crossref]
  3. 2021 - A critical review of radiation therapy: From particle beam therapy (proton, carbon, and BNCT) to beyond [Crossref]
  4. 2013 - Assessment of organ dose reduction and secondary cancer risk associated with the use of proton beam therapy and intensity modulated radiation therapy in treatment of neuroblastomas [Crossref]
  5. 2021 - Variable rbe in proton therapy: Comparison of different model predictions and their influence on clinical-like scenarios [Crossref]
  6. 2017 - Phenomenon-based evaluation of relative biological effectiveness of ion beams by means of the multiscale approach [Crossref]
  7. 1996 - Simultaneous macro and micro dosimetry with MOSFETs [Crossref]
  8. 2023 - State-of-the-art and potential of experimental microdosimetry in ion-beam therapy [Crossref]
  9. 2020 - Characterizing radiation effectiveness in ion-beam therapy Part II: Microdosimetric detectors [Crossref]