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6CCVD Research

Development of a diamond waveguide sensor for sensitive protein analysis using IR quantum cascade lasers

At a Glance

Section titled ā€œAt a Glanceā€
MetadataDetails
Publication Date2018-02-22
AuthorsPierre Piron, Ernesto Vargas CatalĆ”n, Fredrik Nikolajeff, Lars Ɩsterlund, Per Ola Andersson
InstitutionsUppsala University, Molecular Fingerprint (Sweden)
Citations5

Abstract

Section titled ā€œAbstractā€

Microfabricated diamond waveguides, between 5 and 20 Ī¼m thick, manufactured by chemical vapor deposition of diamond, followed by standard lithographic techniques and inductively coupled plasma etching of diamond, are used as bio-chemical sensors in the mid infrared domain: 5-11 Ī¼m. Infrared light, emitted from a broadly tunable quantum cascade laser with a wavelength resolution smaller than 20 nm, is coupled through the diamond waveguides for attenuated total reflection spectroscopy. The expected advantages of these waveguides are a high sensitivity due to the high number of internal reflections along the propagation direction, a high transmittance in the mid-IR domain, the bio-compatibility of diamond and the possibility of functionalizing the surface layer. The sensor will be used for analyzing different forms of proteins such as Ī±-synuclein which is relevant in understanding the mechanism behind Parkinsonā€™s disease. The fabrication process of the waveguide, its characteristics and several geometries are introduced. The optical setup of the biosensor is described and our first measurements on two analytes to demonstrate the principle of the sensing method will be presented. Future use of this sensor includes the functionalization of the diamond waveguide sensor surface to be able to fish out alpha-synuclein from cerebrospinal fluid.

Tech Support

Section titled ā€œTech Supportā€

Original Source

Section titled ā€œOriginal Sourceā€

References

Section titled ā€œReferencesā€
  1. 1998 - Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders
  2. 2014 - Diamonds are a spectroscopistā€™s best friend : thin-film damond mid infrared waveguides for advanced chemical sensors/biosensors
  3. 2016 - Waveguides in poh/cristalline diamond for mid-ir sensing

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