The influence of small amount of substances present in tissue on immunosuppressive drug optical spectrum
At a Glance
Section titled âAt a Glanceâ| Metadata | Details |
|---|---|
| Publication Date | 2018-10-01 |
| Journal | Photonics Letters of Poland |
| Authors | Marcin Marzejon, MaĹgorzata Szczerska |
| Institutions | Polish Academy of Sciences, GdaĹsk University of Technology |
Abstract
Section titled âAbstractâIn this paper, we describe how commonly present in tissue substances - sodium chloride and glucose - affect the optical spectrum of an immunosuppressive drug (CyclaidÂŽ by Apotex). Prepared samples were investigated using the spectrophotometer in the spectrum range from 250 nm to 1100 nm. The maximum wavelength shift calculated on the basis of measurement results is not bigger than the measurement wavelength step. So, it can be concluded, that the small amount of sodium chloride or glucose does not influence the measurement and it is possible to apply spectrophotometry in a point-of-care sensor of the CyclaidÂŽ by Apotex level. Full Text: PDF ReferencesL. Taylor, C. J. E. Watson, and J. A. Bradley, âImmunosuppressive agents in solid organ transplantation: Mechanisms of action and therapeutic efficacyâ, Crit. Rev. Oncol. Hematol. 56, 23 (2005). CrossRef C. C. Mok, âCalcineurin inhibitors in systemic lupus erythematosusâ, Best Pract. Res. Clin. Rheumatol. 31, 429 (2017). CrossRef C. E. M. Griffiths et al., âStriae gravidarum in primiparaeâ, Br. J. Dermatol. 155, 1 (2006). CrossRef F. Stucker and D. Ackermann, âImmunsuppressiva - Wirkungen, Nebenwirkungen und Interaktionenâ, Ther. Umschau. Rev. theĚrapeutique, 68 ,679 (2011). CrossRef A. Fahr, âCyclosporin Clinical Pharmacokineticsâ, Clin. Pharmacokinet. 24, 472 (1993). CrossRef Cyclosporine - UpToDate, DirectLink P. Strakowska, R. Beutner, M. Gnyba et al., âElectrochemically assisted deposition of hydroxyapatite on Ti6A14V substrates covered by CVD diamond films - coating characterization and first cell biological resultsâ, Mater Sci Eng C Mater Biol Appl. 59, 624 (2016). CrossRef M. Gnyba, M. S. WrĂłbel, K. Karpienko et al., âCombined analysis of whole human blood parameters by Raman spectroscopy and spectral-domain low-coherence interferometryâ, Proc. SPIE 9537, 95371N (2015). CrossRef M. S. WrĂłbel, M. Gnyba, R. Urniaz et al., âDetection of propofol concentrations in blood by Raman spectroscopyâ, Proc. SPIE 9537, 95370Z (2015). CrossRef M. Gnyba, et al., âSAVE TO MY LIBRARY Raman spectroscopic investigation of blood and related materialsâ, Proc. SPIE 9448, 944809 (2015). CrossRef H. S. Cho et al., âHigh frame-rate intravascular optical frequency-domain imaging in vivoâ, Biomed. Opt. Express 5, 223 (2013). CrossRef T. A. Valdez et al., âMulti-color reflectance imaging of middle ear pathology in vivoâ, Anal. Bioanal. Chem. 407, 3277 (2015). CrossRef M. Ali Ansari, S. Alikhani, and E. Mohajerani, âA hybrid imaging method based on diffuse optical tomography and optomechanical method to detect a tumor in the biological phantomâ, Opt. Commun. 342, 12 (2015). CrossRef M. S. WrĂłbel et al., âMulti-layered tissue head phantoms for noninvasive optical diagnosticsâ, J. Innov. Opt. Health Sci. 08, 1541005 (2015). CrossRef D. A. Skoog, F. J. Holler, and S. R. Crouch, Principles of instrumental analysis, (Belmont, CA, Thomson Brooks/Cole 2007). CrossRef M. Hof, Basics of Optical Spectroscopy in Handbook of Spectroscopy, (Weinheim , Wiley-VCH Verlag GmbH & Co. KGaA 2005). CrossRef M. Marzejon et al,. âOptical-Spectrometry-Based Method for Immunosuppressant Medicine Level Detection in Aqueous Solutionsâ, Sensors, 18, 2001 (2018). CrossRef UV-9000 Double Beam UV/VIS, http://en.metash.com/ProductShow_172.html CrossRef