Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2022-01-26 |
| Journal | Proceedings of the National Academy of Sciences |
| Authors | Sanyou Chen, Wan-He Li, Xiaohu Zheng, Pei Yu, Pengfei Wang |
| Institutions | Suzhou University of Science and Technology, University of Science and Technology of China |
| Citations | 45 |
Abstract
Section titled āAbstractāSignificance Understanding cancerās biomarker, microenvironment, and heterogeneity at the tissue level promises to improve cancer biology and clinical diagnosis and treatment. Many histological imaging techniques have been developed for this purpose. In this study, benefiting from the development of quantum sensing with nitrogen-vacancy (NV) centers in diamond, we proposed and experimentally realized micrometer-resolution magnetic imaging of tumor tissues in an NV-diamond magnetic microscope, magnetically imaging and quantifying cancer biomarkers. Moreover, we achieved the correlated magnetic and optical imaging in the same tissue section. The histological magnetometry exhibits excellent signal stability, negligible magnetic background, and accurate magnetic quantification. Our method thus opens the door to micrometer-resolution magnetic imaging of biological tissues and has the potential to influence research and histopathology of cancer.
Tech Support
Section titled āTech SupportāOriginal Source
Section titled āOriginal SourceāReferences
Section titled āReferencesā- 2012 - The Essential Physics of Medical Imaging
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