Skip to content
6CCVD Research

Characterization of the PTB ultra-high pulse dose rate reference electron beam

At a Glance

Section titled ā€œAt a Glanceā€
MetadataDetails
Publication Date2022-03-15
JournalPhysics in Medicine and Biology
AuthorsAlexandra Bourgouin, A. Knyziak, M. Marinelli, Rafael Kranzer, Andreas SchĆ¼ller
InstitutionsPius Hospital Oldenburg, Physikalisch-Technische Bundesanstalt
Citations20

Abstract

Section titled ā€œAbstractā€

Abstract Purpose . This investigation aims to present the characterisation and optimisation of an ultra-high pulse dose rate (UHPDR) electron beam at the PTB facility in Germany. A Monte Carlo beam model has been developed for dosimetry study for future investigation in FLASH radiotherapy and will be presented. Material and methods . The 20 MeV electron beams generated by the research linear accelerator has been characterised both in-beamline with profile monitors and magnet spectrometer, and in-water with a diamond detector prototype. The Monte Carlo model has been used to investigate six different setups to enable different dose per pulse (DPP) ranges and beam sizes in water. The properties of the electron radiation field in water have also been characterised in terms of beam size, quality specifier R 50 and flatness. The beam stability has also been studied. Results . The difference between the Monte-Carlo simulated and measured R 50 was smaller than 0.5 mm. The simulated beam sizes agreed with the measured ones within 2 mm. Two suitable setups have been identified for delivering reference UHPDR electron beams. The first one is characterised by a SSD of 70 cm, while in the second one an SSD of 90 cm is used in combination with a 2 mm aluminium scattering plates. The two set-ups are quick and simple to install and enable an expected overall DPP range from 0.13 Gy up to 6.7 Gy per pulse. Conclusion . The electron beams generated by the PTB research accelerator have shown to be stable throughout the four-months length of this investigation. The Monte Carlo models have shown to be in good agreement for beam size and depth dose and within 1% for the beam flatness. The diamond detector prototype has shown to be a promising tool to be used for relative measurements in UHPDR electron beams.

Tech Support

Section titled ā€œTech Supportā€

Original Source

Section titled ā€œOriginal Sourceā€

References

Section titled ā€œReferencesā€
  1. 1999 - AAPMā€™s TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams [Crossref]
  2. 2000 - Absorbed dose determination in external beam radiotherapy: an international code of practice for dosimetry based on standards of absorbed dose to water
  3. 2006 - Uncertainties in alanine/ESR dosimetry at the physikalisch-technische bundesanstalt [Crossref]
  4. 2016 - The FLUKA code: an accurate simulation tool for particle therapy [Crossref]
  5. 2020 - Calorimeter for real-time dosimetry of pulsed ultra-high dose rate electron beams [Crossref]
  6. 2019a - Clinical translation of FLASH radiotherapy: why and how? [Crossref]
  7. 2019b - Treatment of a first patient with FLASH-radiotherapy [Crossref]
  8. 2020 - FLASH radiotherapy with electrons: issues related to the production, monitoring, and dosimetric characterization of the beam [Crossref]
  9. 2014 - Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice [Crossref]
  10. 2019 - Time-resolved dosimetry of pulsed electron beams in very high dose-rate, FLASH irradiation for radiotherapy preclinical studies [Crossref]

Reads Similar to This

Monte Carlo study of microdosimetric diamond detectors A Monte Carlo study on the PTW 60019 microDiamond detector Static small radiation fields and detectors for relative small field dosimetry in external beam radiotherapy