On the microdosimetric characterisation of the radiation quality of a carbon-ion beam and the effect of the target volume thickness
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2024-11-22 |
| Journal | Physics in Medicine and Biology |
| Authors | Gabriele Parisi, Giulio Magrin, C. Verona, G. VeronaāRinati, Sandra Barna |
| Institutions | UniversitƤtszahnklinik Wien, University of Surrey |
| Citations | 3 |
Abstract
Section titled āAbstractāAbstract Objective. Microdosimetry is gaining increasing interest in particle therapy. Thanks to the advancements in microdosimeter technologies and the increasing number of experimental studies carried out in hadron therapy frameworks, it is proving to be a reliable experimental technique for radiation quality characterisation, quality assurance, and radiobiology studies. However, considering the variety of detectors used for microdosimetry, it is important to ensure the consistency of microdosimetric results measured with different types of microdosimeters. Approach. This work presents a novel multi-thickness microdosimeter and a methodology to characterise the radiation quality of a clinical carbon-ion beam. The novel device is a diamond detector made of three sensitive volumes (SVs) of different thicknesses: 2, 6 and 12 Āµ m. The SVs, which operate simultaneously, were accurately aligned and laterally positioned within 3 mm. This alignment allowed for a comparison of the results with a negligible impact of the SVs alignment and their lateral positioning, ensuring the homogeneity of the measured radiation quality. An experimental campaign was carried out at MedAustron using a carbon-ion beam of typical clinical energy (284.7 MeV u ā1 ). Main results. The measurement results allowed for a meticulous interpretation of its radiation quality, highlighting the effect of the SV thickness. The consistency of the microdosimetric spectra measured by detectors of different thicknesses is discussed by critically analysing the spectra and the differences observed. Significance. The methodology presented will be highly valuable for future experiments investigating the effects of the target volume size in radiobiology and could be easily adapted to the other particles employed in hadron therapy for clinical (i.e. protons) and for research purposes (e.g. helium, lithium and oxygen ions).
Tech Support
Section titled āTech SupportāOriginal Source
Section titled āOriginal SourceāReferences
Section titled āReferencesā- 2021 - Linking microdosimetric measurements to biological effectiveness in ion beam therapy: a review of theoretical aspects of MKM and other models [Crossref]
- 2021 - The effect of different lower detection thresholds in microdosimetric spectra and their mean values [Crossref]
- 2017 - Correction factors to convert microdosimetry measurements in silicon to tissue in 12C ion therapy [Crossref]
- 2020 - The impact of sensitive volume thickness for silicon on insulator microdosimeters in hadron therapy [Crossref]
- 1983 - ICRU report 36: microdosimetry [Crossref]
- 2023 - ICRU report 98, stochastic nature of radiation interactions: microdosimetry [Crossref]
- 2015 - Influence of the physical data to calibrate tepcs [Crossref]
- 2013 - Lineal energy calibration of mini tissue-equivalent gas-proportional counters (TEPC) [Crossref]
- 1994 - Inherent calibration of microdosemeters for dose distribution in lineal energy [Crossref]