Equine non-healing corneal ulcers - a retrospective evaluation of 57 cases (2001–2017)
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2020-04-01 |
| Journal | Tierärztliche Praxis Ausgabe G Großtiere / Nutztiere |
| Authors | Vera J. S. Prucha, Alexander Tichy, Barbara Nell |
| Institutions | MODUL University Vienna |
| Citations | 2 |
Abstract
Section titled “Abstract”Abstract Background and objectives Non-healing corneal ulcers (NHCU) are a common problem in equine practice and several treatment options are available with different success and healing times. The aim of this retrospective study was to evaluate and to compare treatment protocols, clinical courses, corneal healing time and outcomes of NHCU. Methods From December 2001 to December 2017, a total of 57 horses with NHCU were presented at the Vetmeduni Vienna. Recorded data included affected eye, signalment, clinical symptoms, season of diagnosis, treatment protocols, complications and corneal healing rate. Results Sixty-three eyes were diagnosed with a NHCU. Follow-up information was available for 48/63 eyes. For those treated medically mean corneal healing time was 15.7 days (± SD 12.0). Medical treatment included topical antibiotics, antimycotics, cycloplegics, and systemic anti-inflammatory drugs. Twelve eyes received treatment with a poly-carboxymethylglucose-sulfate regenerating agent (Cacicol®; Thea Pharma GmbH, Wien, Austria). Other common additional treatments included debridement with an iodine drenched cotton tip (48 eyes; 76.2 %) and diamond burr debridement (30 eyes; 47.6 %). A bandage contact lens (BCL) was used for 10 eyes. Each eye received at least one additional treatment, although none of them led to a statistically significant alteration in healing time. Only usage of a BCL significantly increased healing time when compared to not using a BCL (p = 0.035). When all treatments failed, superficial keratectomy with placement of a conjunctival flap was performed. Secondary complications included stromal cellular infiltration, keratomycosis, keratomalacia, and corneal abscess formation. Conclusions Results correlated with those previously described and thus demonstrated the difficulty and complexity of this disease. Further research is needed to determine an optimal treatment protocol for non-healing ulcers in horses. Clinical relevance Since NHCUs are a commonly encountered problem in equine practice a reliable treatment protocol is required. This study reflects the problems with those ulcers and provides several protocols for possible treatments.
Tech Support
Section titled “Tech Support”Original Source
Section titled “Original Source”References
Section titled “References”- 2012 - Topical Treatment with a New Matrix Therapy Agent (RGTA) for the Treatment of Corneal Neurotrophic Ulcers [Crossref]
- 2016 - Matrix Regenerating Therapy: A Case Series of Corneal Neorotrophic Ulcers [Crossref]
- 2015 - A pharmacological modification of pain and epithelial healing in contemporary transepithelial all-surface laser ablation (ASLA) [Crossref]
- 2006 - Les agents de régénération (ou RGTAs): une nouvelle approche thérapeutique [Crossref]
- 2017 - RGTA® or ReGeneraTing Agents mimic heparan sulfate in regenerative medicine: from concept to curing patients [Crossref]
- 2001 - Morphology and immunohistochemistry of spontaneous chronic corneal epithelial defects (SCCED) in dogs
- 2005 - Effects of RGTA OTR4131 on Ocular Surface: in vivo Evaluation on a Rabbit corneal Wound Healing Model and in vitro Toxicological Studies
- 2002 - Cyanoacrylate tissue adhesive for treatment of refractory corneal ulceration [Crossref]
- 1999 - Equine ophthalmology
- 2007 - Grid keratotomy as a treatment of superficial nonhealing corneal ulcers in 10 horses [Crossref]