Multiplexed sensing of biomolecules with optically detected magnetic resonance of nitrogen-vacancy centers in diamond
At a Glance
Section titled āAt a Glanceā| Metadata | Details |
|---|---|
| Publication Date | 2021-12-13 |
| Journal | Proceedings of the National Academy of Sciences |
| Authors | Metin Kayci, Jilin Fan, Onur Bakirman, Andreas Herrmann |
| Institutions | RWTH Aachen University, DWI ā Leibniz Institute for Interactive Materials |
| Citations | 26 |
Abstract
Section titled āAbstractāSignificance Bioassay applications that use magnetic nanotags to convert specific molecular interactions into a detectable magnetic dipole represent a rapidly advancing field of nanotechnology to develop next-generation diagnostics while providing the capability for simultaneous noninvasive manipulation in an external magnetic field. Although absorption, autofluorescence, scattering, photobleaching, blinking, and chemical quenching are major noise components for fluorescent markers in thick and opaque heterogeneous biological samples, they are not the significant limiting factors for the magnetic detection systems using magnetic nanotags. Here, we report progress toward a multiplexed magneto-DNA assay platform with position-indexed hydrogel microstructures decorated for sequence-specific nucleic acid detection and a complementary magnetic-imaging system using nitrogen-vacancy quantum centers in diamond.