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6CCVD Research

Use of autologous serum or Vizoovet to improve healing rates of spontaneous chronic corneal epithelial defects after diamond burr debridement in dogs

At a Glance

Section titled “At a Glance”
MetadataDetails
Publication Date2021-11-16
JournalVeterinary Ophthalmology
AuthorsD. Dustin Dees, Deborah A. Keys
InstitutionsLeidos (United States), Eye Care Associates
Citations6

Abstract

Section titled “Abstract”

Abstract Purpose To determine whether the use of autologous serum or VizoovetÂź improved healing rates of spontaneous chronic corneal epithelial defects (SCCEDs) after diamond burr debridement (DBD) in dogs. Study design Two parallel group randomized prospective study with a historical control group. Materials and methods Canine patients having undergone DBD for treatment of SCCEDs were included. Data for the control group (ofloxacin only) were gathered from patient records. Patients were randomly assigned to treatment groups for post‐procedural medical treatments of ofloxacin and autologous serum (group 1) or ofloxacin and VizoovetÂź, an all‐natural eyed drop containing propolis, aloe vera, and chamomile (group 2). Each dog was examined between 2 and 3 weeks until the cornea was fluorescein stain negative. Data points collected included age, sex, breed, type of medications used, retention of bandage contact lens (BCL), time to healing, and number of DBD performed. Results A total of 120 dogs, each contributing one eye to the study, underwent DBD for SCCEDs. Mean (± standard deviation) days until healed were 20.1 ± 11.1 days, 16.3 ± 4.5 days, and 16.0 ± 3.7 days for the control group, group 1, and group 2, respectively. There was a marginally significant difference in days until healed between groups ( p = .0515). SCCEDs healed significantly faster in group 2 ( p = .03) and marginally faster in group 1 ( p = .06) compared with the control group. Days until healing between group 1 and 2 were not significantly different ( p = .76). Conclusions As compared to the control group, use of VizoovetÂź as adjunctive medical treatment resulted in shorter corneal healing time after DBD.

Tech Support

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Original Source

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References

Section titled “References”
  1. 2013 - Veterinary Ophthalmology
  2. 2001 - Morphology and immunohistochemistry of spontaneous chronic corneal epithelial defects (SCCED) in dogs
  3. 2001 - Spontaneous chronic corneal epithelial defects (SCCED) in dogs: clinical features, innervation, and effect of topical SP, with or without IGF‐1

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