Detection of Glucose Using Diamond Solution-Gate Field-Effect Transistor
At a Glance
Section titled “At a Glance”| Metadata | Details |
|---|---|
| Publication Date | 2022-06-29 |
| Journal | IEEE Transactions on Electron Devices |
| Authors | Qianwen Zhang, Xiaohui Chang, Bangqiang Xu, Yanfeng Wang, Dan Zhang |
| Institutions | Xi’an Jiaotong University, Shaanxi Provincial People’s Hospital |
| Citations | 3 |
Abstract
Section titled “Abstract”The concentration of glucose was detected using an H-terminated diamond solution-gate field-effect transistor (H-diamond SGFET). The linker molecular 1-pyrenebutyric acid-N-hydroxy succinimide ester (Pyr-NHS) was introduced to modify the H-diamond surface. Then, glucose oxidase (GOD) was immobilized on the diamond surface by linker Pyr-NHS. Atomic force microscope and scanning electron microscope measurements confirmed the successful immobilization of Pyr-NHS and GOD enzyme on the H-diamond surface. The concentration of glucose was determined by the shift of gate voltage ( <inline-formula xmlns:mml=“http://www.w3.org/1998/Math/MathML” xmlns:xlink=“http://www.w3.org/1999/xlink”> <tex-math notation=“LaTeX”>${V}{\text {GS}}$ </tex-math></inline-formula> ) in transfer characteristics of H-diamond SGFET. Also, the sensitivity of sensor for glucose detection was obtained as −58.69 mV/ <inline-formula xmlns:mml=“http://www.w3.org/1998/Math/MathML” xmlns:xlink=“http://www.w3.org/1999/xlink”> <tex-math notation=“LaTeX”>${\text {log}}{{10}}$ </tex-math></inline-formula> (glucose concentration) by the slope of fitting curve, which represented the relationship between <inline-formula xmlns:mml=“http://www.w3.org/1998/Math/MathML” xmlns:xlink=“http://www.w3.org/1999/xlink”> <tex-math notation=“LaTeX”>${\Delta {V}}{\text {GS}}$ </tex-math></inline-formula> and logarithmic of glucose with concentration increasing from 1 <inline-formula xmlns:mml=“http://www.w3.org/1998/Math/MathML” xmlns:xlink=“http://www.w3.org/1999/xlink”> <tex-math notation=“LaTeX”>$\times 10^{-{3}}$ </tex-math></inline-formula> to 1 M. The reusability of device was characterized by the transfer properties and small standard deviation (SD) of maximum output current ( <inline-formula xmlns:mml=“http://www.w3.org/1998/Math/MathML” xmlns:xlink=“http://www.w3.org/1999/xlink”> <tex-math notation=“LaTeX”>${I}{\text {DS(max)}}$ </tex-math></inline-formula> ) in four tests, indicating excellent reusability for detection of glucose.
Tech Support
Section titled “Tech Support”Original Source
Section titled “Original Source”References
Section titled “References”- 1998 - Evaluation of a home kit blood glucose monitoring device